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「毒の致死量」ってどうやって調べるの? 死ぬまで摂取してみるの?

どうやら危険な人体実験の結果……ではないらしい。

» 2017年11月17日 11時00分 公開
[QuizKnockねとらぼ]

 世の中にはさまざまな「毒」があり、それぞれに「これ以上は死ぬぞ」というラインである「致死量」が知られています。猛毒のシアン化カリウム(いわゆる青酸カリ)なら、致死量は成人で0.2~0.3グラムとされています。

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 改めて考えてみると致死量を測るためには、毒を少しずつ与えて死に至ったときの投与量を得る必要があります。これを人に対してやったとしたら……考えるだけで恐ろしい話です。

 実際、第二次世界大戦時のドイツのデータなどは存在しますが、現代で公式に実験することは不可能でしょう。では、致死量は一体どのように測定しているのでしょうか。

致死量は振れ幅が大きい

 そもそも大前提として、毒の効きやすさは動物の種類、体重、体質、体調……など、あらゆる要因によって変化します。つまり、青酸カリの致死量は前述の通り約0.3グラムとされていますが、人によっては0.5グラム飲んでも死なないかもしれないし、逆に0.1グラムだけで死に至ってしまう場合もあるのです。

 そこで、致死量を表すときには「ある動物の集団に一斉に与えたとき、半分が死に至る量」が用いられます。これを半数致死量といい、よく「LD50」と書かれます。英語で致死量を意味する「Lethal Dose」の頭文字、「50%」を使った略語。

さすがに人間では試せない

 LD50を測定するには一定数の動物を殺さなければいけないので、基本的に人間ではできません。人間のデータがない場合、マウスなどの実験動物のデータから、体重1キロ当たりの致死量をもとに推定することになります。

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 人間と他の動物では毒の効き方は違うので、多くの致死量はあくまで参考ということになります。フィクション作品でよく見る「致死量ギリギリの毒を飲み続けてきたから毒は効かないぜ」ってやつ、素人はやらないほうが良さそうです(当たり前)。

あなたのそばにも致死量

 毒になるおそれがあるものに極力近づかないほうがいいのは当然ですが、少量の毒を有効活用している例もあります。

 有名なケースでは、超猛毒のボツリヌストキシン(ボツリヌス菌が発する毒素)を数百倍に薄めた注射薬が、けいれんの治療や顔のシワ取りなどに用いられています。

 逆に、適量なら身体に有用な物質にも致死量が存在。例えば、コーヒーに含まれるカフェインは、3時間以内に1グラム(コーヒー換算10杯)以上摂取すると中毒が発生し、10グラム(コーヒー換算100杯)摂取すると死に至るとされています(※)。

 また、食塩は約200グラムが致死量。これはハッピーターン約3300個分の塩分量で、3時間で摂取しようとしたら3秒に1つのペースで食べ続けなければなりません。ちなみに、食塩中毒には確立された治療法がまだないそうな。恐ろしいというべきか、ピンと来ないというべきか……。

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※コーヒー1杯に含まれるカフェインを約0.1グラムで計算

コーヒー(カフェイン)や塩にも致死量がある

 カフェインにしろ食塩にしろ普通なら達しない量ですが、一応気をつけましょう。概して推定量であり、個人差も大きいので、良い子のみんなは「致死量チキンレース」とかしちゃダメだぞ。

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  7. /nl/articles/2502/19/news004.jpg 古いタオルを切り出すと……? “全く別の日用品”に生まれ変わる技に「素晴らしいアイデア」「最高!」と340万再生
  8. /nl/articles/2502/20/news074.jpg 大阪・梅田のど真ん中で派手にスカート裂けた → 笑うしかない大失態に「ちょ待てよ」「こうなった時の気持ち考えて」
  9. /nl/articles/2502/20/news091.jpg すっぴんボサボサのママがメイクをしたら…… 目を疑う“衝撃の変身”が250万再生「飲み物吹いたw」「同一人物と思えない」【海外】
  10. /nl/articles/2502/20/news031.jpg ホームセンターで買った“最強の掃除屋”を水槽に入れたら…… 驚きの変化に「便利」「試してみます」の声
先週の総合アクセスTOP10
  1. 最初に軽く結ぶだけで…… 2000万再生された“マフラーの巻き方”に反響「これは使える」「素晴らしいアイデア」【海外】
  2. コメダ珈琲店で朝、ミックスサンドとコーヒーを頼んだら…… “とんでもない事態”に爆笑「恐るべし」「コントみたい」
  3. 「14歳でレコ大受賞」 人気アイドルがセクシー女優に転身した理由明かす 家族、メンバー、ファンの“意外な反応”
  4. 雑草ボーボーの荒れ地に“牛3頭”を放牧→2週間後…… まさかの光景に「感動しました」「いい仕事してますねぇ~!!」
  5. “この子はきっと中型犬サイズ”と思っていたら……たった半年後とんでもない姿に 「笑わせてもらいました」
  6. 年の差21歳で「夫は娘の同級生」 “両親大激怒”で結婚は猛反発されるも……“まさかの行動”で説得
  7. 163センチ、63キロの女性が「武器はメイクしかない」と本気でメイクしたら…… 驚きの仕上がりに「やっば、、」「綺麗って声でた」
  8. サイゼリヤ、メニュー改定で“大人気商品”消える 「ショック」悲しみの声……“代わりの商品”は評価割れる
  9. ママが反抗期の娘に作った“おふざけ弁当”がギミックてんこ盛りの怪作で爆笑 娘「教室全員が見に来た」
  10. 「さすがに無神経な内容」 “暴言受けた”伊藤友里が降板発表→岡田紗佳の直後の投稿に批判の声 Mリーガーも反応
先月の総合アクセスTOP10
  1. ドブで捕獲したザリガニを“清らかな天然水”で2週間育てたら…… 「こりゃすごい」興味深い結末が195万再生「初めて見た」
  2. 「配慮が足りない」 映画の入場特典で「おみくじ」配布→“大凶”も…… 指摘受け配給元謝罪「深くお詫び」
  3. 母「昔は何十人もの男性の誘いを断った」→娘は疑っていたが…… 当時の“モテ必至の姿”が1170万再生「なんてこった!」【海外】
  4. 風呂に入ろうとしたら…… 子どもから“超高難易度ミッション”が課されていた父に笑いと同情 「父さんはどのようにしてこのお風呂に入るのか」
  5. 母親から届いた「もち」の仕送り方法が秀逸 まさかの梱包アイデアに「この発想は無かった」と称賛 投稿者にその後を聞いた
  6. 市役所で手続き中、急に笑い出した職員→何かと思って横を見たら…… 衝撃の光景が340万表示 飼い主にその後を聞いた
  7. 「ごめん母さん。塩20キロ届く」LINEで謝罪 → お母さんからの返信が「最高」「まじで好きw」と話題に
  8. DIYで室温が約10℃変わった「トイレの寒さ対策」が310万再生 コスパ最強のアイデアへ「天才!」「これすごくいい」
  9. 「こんなおばあちゃん憧れ」 80代女性が1週間分の晩ご飯を作り置き “まねしたくなるレシピ”に感嘆「同じものを繰り返していたので助かる」
  10. 岡田紗佳、生配信での発言を謝罪 「とても不快」「暴言だと思う」「残念すぎ」と物議